Location: Redwood City, California or Remote

Rezolute is a late-stage rare disease company focused on significantly improving outcomes for individuals with hypoglycemia caused by hyperinsulinism (HI). Our antibody therapy, RZ358 (ersodetug), is designed to treat all forms of HI and has shown substantial benefit in clinical trials and real-world use for the treatment of congenital hyperinsulinism (cHI) and tumor hyperinsulinism (tumorHI).

The Director of Medical Affairs will play a pivotal role in working alongside the Head of Medical & Patient Affairs to shape and execute the medical strategy for Rezolute’s rare disease portfolio. This role will assist in leading medical communications, ensuring scientific accuracy in external communications and messaging, engaging with key opinion leaders (KOLs) and other key healthcare professionals (HCPs), and help oversee a high-performing Medical Science Liaison (MSL) team. This role requires a balance of strategic thinking and operational execution, with an emphasis on cross-functional collaboration and stakeholder communication, both internally and externally. . This role will be integral to operationalizing critical components of the medical affairs department to ensure a successful product launch and sustained post-launch support.

Key Responsibilities

The Director of Medical Affairs will contribute to the development and implementation of the portfolio strategy and life cycle management planning across indications. The successful candidate will be responsible for cross-functional communication and collaboration across the organization to ensure the execution of global medical affairs strategies across all geographic regions ensuring a cohesive approach. This role will execute medical affairs activities ensuring partnership within the team (medical strategy, scientific communications and publications) and across all key Medical Affairs functions (Medical Excellence, HEOR, Field Medical, Medical Information) to ensure alignment and one 4DMT approach.

1. Product Launch
   
   • Provide insights into the development and implementation of the medical affairs strategy to support the successful launch of rare disease products.
   • Collaborate cross-functionally with clinical, commercial, and regulatory teams to ensure alignment on pre- and post-launch activities.
   • Provide medical insights and strategic input into product positioning and lifecycle planning.
   • Help guide the creation of medical education and training materials for internal and external stakeholders.
     
2. Medical Communications
   
   • Share in oversight of the development and dissemination of scientifically accurate and compliant medical content, including publications, slide decks, and digital assets.
   • Ensure alignment of medical communications with the company’s broader scientific and clinical objectives.
   • Liaison with external vendors and agencies supporting medical communications and publications.
     
3. Key Opinion Leader (KOL) Engagement
   
   • Develop and maintain strong relationships with global, national, and regional KOLs in the rare disease space.
   • Facilitate scientific exchange and education to advance understanding of the company’s products and therapeutic areas.
   • Identify and collaborate with external experts for advisory boards, symposia, and scientific meetings.
     
4. Medical Science Liaison (MSL) Management
   
   • Guide, mentor, and help manage a team of MSLs to ensure effective field medical engagement and alignment with company goals.
   • Co-develop performance metrics and provide coaching to optimize MSL impact on scientific exchange and KOL engagement.
   • Collate actionable MSL field insights to inform medical and commercial strategies.
     
5. Compliance and Governance
   
   • Ensure all medical affairs activities comply with industry regulations, corporate policies, and ethical standards.
   • Stay current on relevant therapeutic area advancements and regulatory updates.

Qualifications

• Advanced degree (MD, PhD, or PharmD) in a relevant scientific discipline is required.
• Minimum of 7 years of experience in medical affairs within the biopharmaceutical industry, preferably in rare diseases.
• Proven experience with product launches, medical communication, and KOL engagement.
• Strong leadership and team management experience, particularly with Medical Science Liaisons.
• Exceptional communication and interpersonal skills with the ability to influence cross-functional teams.
• Deep understanding of rare disease therapeutic areas and related regulatory requirements.
• Experience in designing and executing advisory boards, symposia, or investigator-initiated studies.
• Familiarity with health economics and outcomes research (HEOR) to support value messaging in rare diseases.
• Demonstrated ability to build strong relationships with external stakeholders, including patient advocacy groups.

To Apply

Interested and qualified candidates should send a resume to recruiting@rezolutebio.com to the attention of Human Resources.

Rezolute (RZLT) currently anticipates the base salary for the Director of Medical Affairs role could range from $235,000 to $260,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate. Rezolute offers competitive compensation, stock options and a rich benefits package.

Qualifying employees are eligible to participate in benefit programs such as:

• Health Insurance (Medical / Dental / Vision)
• Disability, Life & Long-Term Care Insurance
• Holiday Pay
• Tracking Free Vacation Program
• 401(k) Plan Match
• Educational Assistance Benefit
• Fitness Center Reimbursement

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.